METHODS OF TREATING ACUTE MYELOID LEUKEMIA OR ACUTE LYMPHOID LEUKEMIA USING PHARMACEUTICAL COMPOSITIONS CONTAINING THIENOTRIAZOLODIAZEPINE COMPOUNDS

摘要

The present invention relates to a pharmaceutical composition comprising a thienothiazol-zoloidazepine compound represented by the following formula (1) or a pharmaceutically acceptable salt thereof or a hydrate thereof or a solvate thereof in a mammal Acute myelogenous leukemia or acute lymphoblastic leukemia, (One) Wherein R ¹ is alkyl having 1-4 carbon atoms; R ² is a hydrogen atom; A halogen atom; Or alkyl having 1 to 4 carbon atoms optionally substituted by a halogen atom or a hydroxyl group; R ³ is a halogen atom; A halogen atom, alkyl having from 1 to 4 carbon atoms, alkoxy having from 1 to 4 carbon atoms, or cyano; _{^{-NR 5 - (CH 2) m}} -R 6 ( wherein R ⁵ is alkyl having a carbon number of 1-4 or a hydrogen atom, m is an integer from 0-4, R ⁶ is a halogen atom by an optionally substituted phenyl Or pyridyl; Or -NR ⁷ -CO- (CH ₂ ) _n -R ⁸ wherein R ⁷ is a hydrogen atom or alkyl having 1-4 carbon atoms, n is an integer of 0-2 and R ⁸ is optionally substituted with a halogen atom Substituted phenyl or pyridyl; R ⁴ is - (CH ₂ ) _a -CO-NH-R ⁹ , wherein a is an integer from 1-4 and R ⁹ is an alkyl having 1-4 carbon atoms; Hydroxyalkyl having 1 to 4 carbon atoms; Alkoxy having 1 to 4 carbon atoms; Or an alkoxy, amino or hydroxyl groups, or alkyl having a carbon number of 1 to 4 having a carbon number of _{1-4 - (CH 2) b -COOR} 10 ( wherein b is an integer of 1-4, R ¹⁰ is 1- Lt; / RTI is an alkyl having a carbon number of 1 to 4).