fast-acting insulin derivatives, process for their preparation as well as precursor, pharmaceutical preparation, solution for injection and use

摘要

"Insulin derivatives having a rapid onset of action". The present invention relates to insulin derivatives which, in comparison to human insulin, have an accelerated onset of action, a process for their preparation and their use, particularly in pharmaceutical preparations for the treatment of diabetes mellitus. in particular, the present invention relates to insulin derivatives or physiologically tolerable salts thereof in which asparagine (asn) at position b3 of the b chain is replaced by a naturally occurring basic amino acid residue, and at least one amino acid residue at positions b27, b28 or b29 of the b chain is replaced by another naturally occurring amino acid residue and is optionally possible for asparagine (asn) at position 21 in the chain to be replaced by asp, gly, ser, thr, or ala and for phenylalanine ( phe) at position b1 of chain b and amino acid residue at position b30 of chain b are absent.