Method of reducing particle size of (3R)-1-(3-phenoxypropyl)chinuclidin-1-ium-3-yl 2-hydroxy-2,2-bis(2-thienyl)acetate bromide

摘要

ufeffzpu016fsob particle production aklidinium bromide for use in pharmaceutical formulation, the method includes mikronizaci aklidinium bromide with particle size of more than 30.mi.m and conditioning micronised aklidinium bromide to obtain the aklidinium bromide on the size of budget: past stic smaller than 10.mi.m and an amorphous mass of less than 3. %.method of production of pharmaceutical formulation is given below, where aklidinium bromide mixed with at least one pharmaceutically acceptable excipient.