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1,2,4-thiazolidin-3-ONE DERIVATIVES AND THEIR USE IN CANCER TREATMENT
1,2,4-thiazolidin-3-ONE DERIVATIVES AND THEIR USE IN CANCER TREATMENT
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机译:1,2,4-噻唑烷-3-酮衍生物及其在癌症治疗中的用途
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摘要
According to the invention there is provided a compound of formula (I) wherein: A represents C(NW-D) or S; B represents S or C(NHW-D); when: A represents C(NW-D) and B represents S then the bond between B and the NH atom is a single bond; or A represents S and B represents C(NHW-D) then the bond between B and the NH atom is a double bond; X represents -Q-[CRxRy]n; W represents [CRxRy]m or C(O)[CRxRy]p; Q represents a bond, N(Ra), S, or O; A1 to A5 respectively represent C(R1), C(R2), C(R3), C(R4) and C(R5), or, alternatively, up to two of A1 to A5 may independently represent N; D represents phenyl, pyridyl or pyrimidinyl optionally substituted by one or more R6 groups, which compounds are useful in the treatment of cancer.
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