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Liposomes with lipids having a favorable pKa of RNA for bringing
Liposomes with lipids having a favorable pKa of RNA for bringing
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机译:脂质脂质体具有有利的RNA pKa
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摘要
RNA encoding an immunogen is delivered in a liposome for the purposes of immunisation. The liposome includes lipids which have a pKa in the range of 5.0 to 7.6 and, preferably, a tertiary amine. These liposomes can have essentially neutral surface charge at physiological pH and are effective for immunisation.
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