7 - u043cu0435u0442u043eu043au0441u0438 - 1 - methyl - 9H - u043fu0438u0440u0438u0434u043e 3,4 - b u0438u043du0434u043eu043b - 2N - hydrochloride with u0430u043du0442u0438u0434u0435u043fu0440u0435u0441u0441u0438u0432u043du043eu0439, u043fu0440u043eu0442u0438u0432u043eu0433u0438u043fu043eu043au0441u0438u0447u0435u0441u043au043eu0439 and u0430u043du0442u0438u043fu0430u0440u043au0438u043du0441u043eu043du0438u0447u0435u0441u043au043eu0439 activity

摘要

the invention belongs to the field of chemistry u0444u0430u0440u043cu0430u043au043eu043bu043eu0433u0438u0447u0435u0441u043au0438 active u0433u0435u0442u0435u0440u043eu0446u0438u043au043bu0438u0447u0435u0441u043au0438u0445 compounds of natural origin, specifically to u0432u043eu0434u043eu0440u0430u0441u0442u0432u043eu0440u0438u043cu043eu0439 u0447u0435u0442u0432u0435u0440u0442u0438u0447u043d oh form u0430u043bu043au0430u043bu043eu0438u0434u0430 u0433u0430u0440u043cu0438u043du0430: 7 - u043cu0435u0442u043eu043au0441u0438 - 1 - methyl - 9u043d - u043fu0438u0440u0438u0434u043e [3,4 - (b) u0438u043du0434u043eu043b - 2N - u0433u0438u0434u0440u043eu0445u043bu043eu0440u0438u0434u0443, which would broaden the range of medications used for the le of central nervous system diseases.on the basis of available plant u0430u043bu043au0430u043bu043eu0438u0434u0430 u0433u0430u0440u043cu0438u043du0430 synthesized his u0432u043eu0434u043eu0440u0430u0441u0442u0432u043eu0440u0438u043cu0430u044f salt.experimentally, it is found that the compound in doses of 2.5 and 5 mg / kg has u0430u043du0434u0435u043fu0440u0435u0441u0441u0438u0432u043du043eu0439 activity comparable to the activity of elavil in a dose of 10 mg / kg. and is u0430u043du0442u0438u043fu0430u0440u043au0438u043du0441u043eu043du0438u0447u0435u0441u043au043eu0435 effects, comparable with the activity of the drug "l-dopa" in a dose of 50 m / kg, which is expressed with u043au0430u0442u0430u043bu0435u043fu0441u0438u0438 in rats caused by in u0433u0430u043bu043eu043fu0435u0440u0438u0434u043eu043bu043eu043c, and reducing the u043eu043bu0438u0433u043eu043au0438u043du0435u0437u0438u0438 and stiffness in test operationcaused by a neurotoxin and u043cu0444u0442u043f mice line C57BL / 6, and also has u043fu0440u043eu0442u0438u0432u043eu0433u0438u043fu043eu043au0441u0438u0447u0435u0441u043au043eu0439 activity in the test u0433u0438u043fu043eu0431u0430u0440u0438u0447u0435u0441u043au043eu0439 hypoxia, comparable with the activity of mek u0441u0438u0434u043eu043bu0430 in a dose of 100 mg / kg.