NOVEL HUMAN PAPILLOMAVIRUS (HPV) PROTEIN CONSTRUCTS AND THEIR USE IN THE PREVENTION OF HPV DISEASE

摘要

The disclosure provides novel human papillomavirus (HPV) protein constructs and their use in the prevention of HPV disease. The constructs are chimeric proteins comprising L1 proteins with an HPV L2 peptide inserted in to the L1 protein. Such chimeric proteins may be formulated into immunogenic e.g. vaccine compositions, and optionally formulated with HPV L1 VLP based vaccines.