DELIVERY OF IMMUNE DEPRESSORS WITH A DETERMINED PHARMACODYNAMICALLY EFFECTIVE PERIOD AND ANTIGEN FOR INDUCTION OF IMMUNE TOLERANCE

摘要

The present invention relates to methods that provide immunosuppressants and therapeutic macromolecules that are administered within a pharmacodynamically effective window for immunosuppressants to induce immune tolerance to therapeutic macromolecules. The methods allow a shift in the immune response in favor of the development of a tolerogenic immune response specific to the therapeutic macromolecule.