4 - ((2-HYDROXYETHOXY) METHYL) -5-METHYL-2-METHYLMERCAPTO-1,2,4-TRIAZOLO 1,5-a Pyrimidin-7 (4H) -OH, possessing activity in relation to the virus in the case of the unpleasant virus

摘要

The claimed invention relates to the development of a new substance - 4 - ((2-hydroxyethoxy) methyl) -5-methyl-2-methyl mercapto-1,2,4-triazolo [1,5-a] pyrimidine-7 (4H) -one, having formulas for treating West Nile fever in humans and animals. The method of obtaining 4 - ((2-hydroxyethoxy) methyl) -5-methyl-2-methylmercapto-1,2,4-triazolo [1,5-a] pyrimidine-7 (4H) -one consists in deacetylation of 4 - (( 2-acetoxyethoxy) methyl) -5-methyl-2-methylmercapto-1,2,4-triazolo [1,5-a] pyrimidine-7 (4H) -one (II) under the action of a solution of alkali metal methylate in aliphatic monohydric alcohol , while 4 - ((2-acetoxyethoxy) methyl) -5-methyl-2-methylmercapto-1,2,4-triazolo [1,5-a] pyrimidine-7 (4H) -one (II) is obtained by the interaction 5-methyl-2-methylmercapto-1,2,4-triazolo [1,5-a] pyrimidine-7 (4H) -one (III) with (2-acetoxyethoxy) methyl acetate (IV) in the presence of silicium for example, N, O-bis (trimethylsilyl) acetamide (BSA) or hexamethyldisilylamine (HMDS) and trimethylsilyl trifluoromethyl sulfonate (TMSOTf) in an aprotic solvent. The use of 4 - ((2-hydroxyethoxy) methyl) -5-methyl-2-methyl mercapto-1,2,4-triazolo [1,5-a] pyrimidine-7 (4H) -one for the treatment of West Nile fever (LPN) .