STABLE POLYMORF OF SALT (2R) -4-ОКСО-4- 3- (TRIFTOROMETHYL) -5,6-DIHYDRO 1,2,4 TRIAZOLO 4,3-α PYRAZIN-7 (8H) -IL - 1- (2,4,5-TRIFTORPHENYL) BUTAN-2-AMINE AND L-WINE ACID

摘要

Stable polymorph (form Z1) of the salt (2R) -4-oxo-4- [3- (trifluoromethyl) -5,6-dihydro [1,2,4] triazolo [4,3-α] pyrazin-7 (8H) -yl] -1- (2,4,5-trifluorophenyl) butan-2-amine (sitagliptin) and L-tartaric acid of formula 1, which is a very suitable form of the active pharmaceutical ingredient of medicines, mainly intended for the treatment of diabetes 2 type A method of obtaining a stable polymorph (form Z1) of sitagliptin salt and L-tartaric acid, as well as its use for the preparation of a pharmaceutical composition.