Pharmaceutical composition comprising a methotrexate (mtx) active agent and a 2,2-anhydropyrimidine adjuvant for reducing mtx toxicity and use thereof in the preparation of medicaments

摘要

Methods are provided for using methotrexate (MTX) in which reduced host toxicity is observed. Aspects of the methods include administering to a subject an effective amount of MTX in conjunction with a MTX toxicity-reducing adjuvant, such as a 2,2-anhydropyrimidine, a derivative thereof or a uridine phosphorylase inhibitor. Also provided are compositions that find use in practicing embodiments of the invention. The methods and compositions find use in a variety of applications, including the treatment of a variety of different disease conditions.