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Gene expression profile algorithm and test for likelihood of recurrence of colorectal cancer and response to chemotherapy
Gene expression profile algorithm and test for likelihood of recurrence of colorectal cancer and response to chemotherapy
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机译:基因表达谱算法和结直肠癌复发可能性及对化疗的反应测试
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摘要
Algorithm-based molecular assays that involve measurement of expression levels of prognostic and/or predictive genes, or co-expressed genes thereof, from a biological sample obtained from a cancer patient, and analysis of the measured expression levels to provide information concerning the likelihood of recurrence of colorectal cancer and/or the likelihood of a beneficial response to chemotherapy for the patient are provided herein. Methods of analysis of gene expression values of prognostic and/or predictive genes, as well as methods of identifying gene expression-tumor region ratios, tumor-associated stromal surface area, and gene cliques, i.e. genes that co-express with a validated biomarker and thus may be substituted for that biomarker in an assay, are also provided.
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