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Refolding proteins using a chemically controlled redox state
Refolding proteins using a chemically controlled redox state
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机译:使用化学控制的氧化还原状态重折叠蛋白质
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摘要
A method of refolding proteins expressed in non-mammalian cells present in concentrations of 2.0 g/L or higher is disclosed. The method comprises identifying the thiol pair ratio and the redox buffer strength to achieve conditions under which efficient folding at concentrations of 2.0 g/L or higher is achieved and can be employed over a range of volumes, including commercial scale.
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