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Humanized anti-il-10 antibodies for the treatment of systemic lupus erythematosus (sle)
Humanized anti-il-10 antibodies for the treatment of systemic lupus erythematosus (sle)
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机译:人源化抗il-10抗体,用于治疗系统性红斑狼疮(SLE)
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摘要
Provided is a humanized or chimeric antibody or fragment thereof capable of binding to interleukin-10 (IL-10), wherein said antibody or fragment thereof: (i) binds to the same region of IL-10 as the IL-10 receptor (IL-I10Ra) and is not capable of binding IL-10 when the IL-10 is bound to the IL- 10 receptor; and (ii) binds to IL-10 in homodimeric form by binding a discontinuous epitope comprising residues of both monomers. Further provided are related products and methods involving the use of the antibody or fragment thereof.
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