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Parenteral pharmaceutical form which releases aromatase inhibitor and gestagens for the treatment of endometriosis
Parenteral pharmaceutical form which releases aromatase inhibitor and gestagens for the treatment of endometriosis
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机译:释放芳香酶抑制剂和孕激素的肠胃外药物形式,用于治疗子宫内膜异位症
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摘要
The present invention for the treatment of endometriosis relates to providing a parenteral dosage form (delivery system) for the controlled release of an aromatase inhibitor (AI) in a daily release rate that does not induce stimulation of the ovaries by negative feed-back of the pituitary-ovarian-axis (which would cause secretion of gonadotropins and stimulation of ovarian follicular growth) and a gestagen in a daily release rate below the ovulation inhibition dose that provides contraceptive efficacy based on local effects (e.g. reducing and thickening of the cervical mucus impairing sperm ascension, effects on the endometrium and on tubal motility impairing implantation and egg transport).
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