ISOLATION, CHARACTERIZATION AND EVALUATION OF ANTI HEPATOTOXIC PROPERTY OF A NOVEL COMPOUND FLAVARIOPYRANOSTEROL FROM FLAVERIA TRINERVIA C. MOHR

摘要

A new compound referred to as Flavariopyranosterol (a new name given by the inventor), a steroidal glucoside, is isolated from petroleum ether extract of whole plant of eleaveria trinervia (Asteraceae). Various biochemical and histological tests, conducted using albino mice as test animals, have shown that this new compound exhibits significant hepatoprotectivity (anti-hepato toxicity properties). With the help of spectroscopic studies and chem-informatics tools, the structure of this compound has been found to be 5- (17-hydroxy-4,4-dimethyl-2,3,4,5,6,7,8, 9,10,11,12,13,14,15,16,17-tetradecahydro-1 H-cyclopenta[alpha]phenanthren-3-yloxy)-6- hydroxy methyl-tetrahydro-pyran-2,3,4-triol. Its The hepatoprotectivity is confirmed by restoration of levels of liver function markers and hepatic architecture towards normal condition. This property of Flaveriophyranosterol is a good choice of hepatoprotective drug for treatment of jaundice.