COMPOSITIONS COMPRISING METFORMIN AND ROSIGLITAZONE

摘要

A composition comprising: a core which comprises of metformin, rosiglitazone, and pharmaceutically acceptable excipients and permeable coating. The invention further involves a composition comprising a core which comprises of metformin, rosiglitazone,and pharmaceutically acceptable excipients and permeable coating comprising ammonio methacrylate copolymer. A process of manufacturing a tablet comprising metformin and rosiglitazone wherein the process comprises of preparing granules of rosiglitazone by mixing rosiglitazone with molten carrier, preparing granules of metformin, mixing and compression of granules followed by coating with permeable coating.