Cancer cell targeting and modulation of multi drug resistance with hyaluronated liposome

摘要

The present invention provides a hyaluronated liposome composition for target specific delivery of anticancer agent in CD44 overexpressing cells preferably cancer cell, comprising a phospholipid bilayer vesicle coated with hyaluronic acid, containing respective anticancer agent complex, wherein: - the core of the body comprise of phospholipid bilayer, drug was encapsulated as a charged complex, core liposome was coated with hyaluronic acid - the amount of lecithin vary from 0.5 % to 1 %, - the ratio of aqueous to organic phase may be ranging from 10:1 to 10:3, - the amount of hyaluronic acid vary from 0.0003 % to 0.0067 % - the particle size of core cationic liposome vary from 50 to 200 nm - the entrapment efficiency of drug in liposome vary from 75 % to 100 % - the particle size of hyaluronated liposomes vary from 155 to 600 nm