Nanoparticulate pharmaceutical compositions of aprepitant

摘要

The present invention relates to a nanoparticulate pharmaceutical composition comprising aprepitant and at least one surface stabilizer and a method for preparing such composition. The invention is further directed to a pharmaceutical dosage form comprising a nanoparticulate pharmaceutical composition of aprepitant, a surface stabilizer adsorbed on the surface of aprepitant and a pharmaceutically acceptable excipient. The pharmaceutical composition of the invention is useful in the treatment or prevention of nausea and vomiting.