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THERAPEUTIC AGENT COMPRISING HUMANIZED ANTI EPIREGULIN ANTIBODY AS ACTIVE INGREDIENT FOR NON SMALL CELL LUNG CARCINOMA EXCLUDING ADENOCARCINOMA
THERAPEUTIC AGENT COMPRISING HUMANIZED ANTI EPIREGULIN ANTIBODY AS ACTIVE INGREDIENT FOR NON SMALL CELL LUNG CARCINOMA EXCLUDING ADENOCARCINOMA
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机译:包含人源化抗表皮生长素抗体的治疗剂,作为腺癌除外的非小细胞肺癌的有效成分
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摘要
The present inventors succeeded in producing: an anti Epiregulin antibody exhibiting a cross species reactivity between a non human animal crab eating monkey and a human animal; an anti Epiregulin antibody with suppressed chemical decomposition; an anti Epiregulin antibody having a lowered isoelectric point; an anti Epiregulin antibody having an elevated thermal denaturation midpoint temperature; and an anti Epiregulin antibody having a reduced amount of aggregates by appropriately substituting an amino acid residue in the variable region sequence of a humanized EP27 antibody that is capable of exhibiting a cytotoxic activity and neutralization activity on a cancer cell said cancer cell expressing human Epiregulin to thereby inhibit the proliferation of the cancer cell. Also the present inventors succeeded in creating a therapeutic agent for non small cell lung carcinoma excluding adenocarcinoma said therapeutic agent comprising one of the aforesaid antibodies as an active ingredient.
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