THERAPEUTIC AGENT COMPRISING HUMANIZED ANTI-EPIREGULIN ANTIBODY AS ACTIVE INGREDIENT FOR NON-SMALL-CELL LUNG CARCINOMA EXCLUDING ADENOCARCINOMA

摘要

The present inventors have found that by appropriately substituting the amino acid residues in the variable region sequence of the humanized EP27 antibody which inhibits the proliferation of cancer cells by exhibiting cytotoxic activity and neutralizing activity against cancer cells expressing anti-human epireticin, A pyrethroid antibody, a pyrethroid antibody, an anti-pyrethroid antibody, an anti-pyrethroid antibody, an anti-pyrethroid antibody, an anti-pyrethroid antibody, an anti-pyrethroid antibody, And a therapeutic agent for non-small cell lung cancer other than adenocarcinoma containing the antibody as an active ingredient was successfully produced.