METHOD OF SYNTHESIS OF STABLE FORMS OF LOPERAMIDE N-OXIDE: (4-4-(4-CHLOROPHENYL)-4- HYDROXYPIPERIDIN-1-YL-N,N-DIMETHYL-2,2-DI(PHENYL)BUTANAMIDE) N-OXIDE AND STABLE LOPERAMIDE N-OXIDE MADE THEREBY

摘要

A novel aqueous based method of synthesis A novel method of synthesis of (4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-N,N-dimethyl-2,2-di(phenyl)butanamide) N-oxide (Loperamide N-Oxide is disclosed . The invention also provides the product by the method disclosed. The method to produce the compound is capable of being carried out at low temperatures not exceeding about 50°C.