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HOMO- AND HETERO-POLYAMINO-ACID DERIVATIVES OF FULLERENE С60, METHOD FOR PRODUCING SAME, AND PHARMACEUTICAL COMPOSITIONS BASED ON SAID DERIVATIVES.
HOMO- AND HETERO-POLYAMINO-ACID DERIVATIVES OF FULLERENE С60, METHOD FOR PRODUCING SAME, AND PHARMACEUTICAL COMPOSITIONS BASED ON SAID DERIVATIVES.
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机译:富勒烯π60的均聚和杂多聚酰胺酸衍生物,其制备方法以及基于上述衍生物的药物成分。
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摘要
The invention relates to the pharmaceutical industry and to medicine, specifically to novel homo- and hetero-polyamino-acid derivatives of fullerene С60 of general formula: C60(H)x{NH(CH2)nCOO -}x{NH3 +(L)COOH)}x, where n = 2-5, Ñ = 3, L = -(СÐ�2)m, where m = 1-5, or -CO(CH2)kCH(NH2)-, where k = 1-2, characterized in that the compounds comprise covalently bonded amino-acid groups and polar ionic forms of the amino acids, and also to a method for producing said derivatives, and to the production of pharmaceutical compositions based on same. The method for producing homo- and hetero-polyamino-acid derivatives of fullerene is based on the reaction of a nucleophilic bond of amino acids to fullerene, forming covalently bonded amino-acid derivatives of fullerene, with the subsequent introduction of polar ionic forms of the amino acids. A pharmaceutical composition comprises, as active substance, homo- and hetero-polyamino-acid derivatives of fullerene of formula C60(H)x{NH(CH2)nCOO -}x {NH3 +(L)COOH)}x, where n = 2-5, Ñ = 3, L = -(СÐ�2)m, where m = 1-5, or - CO(CH2)kCH(NH2)-, where k = 1-2.
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