首页> 外国专利> N- (6- ( (2r,3s) -3,4-dihydroxybutan-2-yloxy) -2- (4 - fluorobenzylthio) pyrimidin- 4 - yl) -3- methylazetidine- 1 - sulfonamide as chemokine receptor modulator

N- (6- ( (2r,3s) -3,4-dihydroxybutan-2-yloxy) -2- (4 - fluorobenzylthio) pyrimidin- 4 - yl) -3- methylazetidine- 1 - sulfonamide as chemokine receptor modulator

机译:N-(6-((2r,3s)-3,4-二羟基丁烷-2-基氧基)-2-(4-氟苄硫基)嘧啶-4-基团)-3-甲基氮杂环丁烷-1-磺酰胺作为趋化因子受体调节剂

摘要

Disclosed herein is the pyrimidine sulphonamide compound of formula (I) N-(6-((2R,3S)-3,4-dihydroxybutan-2-yloxy)-2-(4-fluorobenzylthio)pyrimidin-4-yl)-3-methylazetidine-1-sulfonamide or a pharmaceutically acceptable salt thereof, crystalline forms of the compound, processes for obtaining the compound, pharmaceutical intermediates used in the manufacture of the compound, and pharmaceutical compositions containing the compound. The compound is intended of use in the treatment of a disease/condition in which modulation of chemokine receptor activity is beneficial.
机译:本文公开了式(I)的嘧啶磺酰胺化合物N-(6-((2R,3S)-3,4-二羟基丁烷-2-基氧基)-2-(4-氟苄硫基)嘧啶-4-基)-3 -甲基氮杂环丁烷-1-磺酰胺或其药学上可接受的盐,化合物的结晶形式,获得该化合物的方法,用于制造该化合物的药物中间体以及包含该化合物的药物组合物。该化合物旨在用于治疗趋化因子受体活性的调节是有益的疾病/病症。

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