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METHODS, DEVICES, AND SYSTEMS FOR BONE TISSUE ENGINEERING USING A BIOREACTOR
METHODS, DEVICES, AND SYSTEMS FOR BONE TISSUE ENGINEERING USING A BIOREACTOR
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机译:使用生物反应器进行骨组织工程的方法,装置和系统
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摘要
An anatomically-shaped, human bone graft may be cultivated ex vivo using a bioreactor capable of perfusing large complex porous scaffolds. Scaffolds derived from image-based modeling of a target are seeded with human mesenchymal stem cells and cultivated. A bioreactor configured to house complex three-dimensional scaffold geometries provides controlled flow for perfusion of the cells. Dense uniform cellular growth can be attained throughout the entire scaffold as a result of the medium perfusion. In an embodiment, the bioreactor has a mold into which perfusion medium is pumped under pressure and multiple ports through which the medium exits the mold.
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