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Cis-bis(3-chloroimidazo1,2-apyridine)dichloroplatinum (II) and methods for producing it

机译:顺式双(3-氯咪唑并[1,2-a]吡啶)二氯铂(II)及其制备方法

摘要

the subject invention is cis bis (3 - chloroimidazo [1,2 - and] pyridine) - dichloroplatyna (ii), cis - [ptcl2 (c7h5n2cl) 2] of formula 1.a first receiving cis bis (3 - chloroimidazo [1,2 - and] pyridine) - dichloroplatyny (ii) of model 1 is that aqueous k2 [ptcl4] undergo fusion reactions with ethanolic solution 3 - chloroimidazo [1,2] pyridine - and model 2 in a mole ratio of 1: 2, with all mixes pr squint a minimum period of 48 hours, maintaining the temperature 120 degrees.a method for obtaining cis bis (3 - chloroimidazo [1,2 - and] pyridine) - dichloroplatyny (ii) of model 1 is that the aqueous solution ptcl4 k2 [] is mixed with previously dissolved in the water.then the following 3 - chloroimidazo [1,2] pyridine - and dissolved in the mixture and etanolowej, after which the product obtained cis - [pti2 (c7h5n2cl) 2], shall be subjected to the reaction with agn03, and in the final stage of odsu0105cza to the crystallized precipitate agi, to filtrate the cis - [pt (c7h5n2cl) 2] (no3) 2, the following solution of kcl in order to obtain the final product, i.e.cis bis (3 - chloroimidazo [1,2 - and] pyridine) - dichloroplatyny (ii), cis - [ptcl2 (c7h5n2cl) 2].
机译:本发明是式1的顺式双(3-氯咪唑[1,2-和]吡啶)-二氯铂(ii),顺式-[ptcl2(c7h5n2cl)2]。首先接受顺式双(3-氯咪唑[1, 2-和[]吡啶)-模型1的二氯铂(ii)是k2 [ptcl4]水溶液与乙醇溶液3-氯咪唑[1,2]吡啶和模型2的摩尔比为1:2的熔融反应,所有混合至少要在48小时内进行,保持温度为120度。模型1的顺式双(3-氯咪唑[1,2-和]吡啶)-二氯铂(ii)的获得方法是水溶液ptcl4将k2 []与先前溶解在水中的混合物混合。然后,将以下3-氯咪唑[1,2]吡啶-溶解在混合物和依他诺洛韦中,然后将产物获得顺式[pti2(c7h5n2cl)2]。进行与agn03的反应,并在ods o105cza的最后阶段结晶出沉淀的agi,以过滤出顺式-[pt(c7h5n2cl)2](为了得到最终产物,需要以下kcl溶液,即顺式双(3-氯咪唑[1,2-和]吡啶)-二氯铂(ii),顺式-[ptcl2(c7h5n2cl)2]。

著录项

  • 公开/公告号PL409928A1

    专利类型

  • 公开/公告日2016-05-09

    原文格式PDF

  • 申请/专利权人 POLITECHNIKA WROCŁAWSKA;

    申请/专利号PL20140409928

  • 发明设计人 DANUTA MICHALSKA-FĄK;MAGDALENA MALIK;

    申请日2014-10-30

  • 分类号C07F15/00;A61P35/00;

  • 国家 PL

  • 入库时间 2022-08-21 14:23:32

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