Cocrystal 4-amino-n-(4,6-dimethylpyrimidin-2-ylo)-benzene-1-sulfonamide-5-nitro-1.3-benzenedicarboxilic acid and method for producing it

摘要

the invention relates to 4 - amino - n - (4,6-dimethylpyrimidin-2-yl) - benzene-1-sulfonamide - acid, 5 - nitro 1,3 - benzenodikarboksylowy of model 1, which is applicable in the pharmaceutical industry.process for the production of kokrysztau0142u also revealed 4 - amino - n - (4,6 - dimetylopitymidyn - 2 - yl) - benzene-1-sulfonamide - acid, 5 - nitro 1,3 - benzenodi - carboxylic model 1 that a 0.1 mmol 4 - amino - n - (4,6-dimethylpyrimidin-2-yl) - benzene - 1 - sulfonamide and 0.1 mmol of 5 - nitro - 1,3 - benzene dikarboksylowego placed, advantageously in a mortar agatowym,then put 2 drops of acetonitrile by approximately 1 minute then whole dissolves in 8 - 10 ml of acetonitrile and subjected to an ultrasound for 2 - 6 seconds, in the next stage, the mixture is mixed at 100 - 300 rpm for about 5 to 15 minutes in temperatu the peaceful, clear solution leaves in order to slow evaporation of solvent in temperature 18 - 20u00b0c,after 4 to 6 days is obtained kokrysztau0142 4 - amino - n - (4,6-dimethylpyrimidin-2-yl) - benzene-1-sulfonamide - acid, 5 - nitro 1,3 - benzenodikarboksylowy as light yellow crystals with regular shape.