PRODUCTION OF NANO- PARTICLES OF SOLID DISPERSIONS AMORFAS BY CONTROLLED CO-PRECIPITATION

摘要

THE INVENTION DETAILS A METHOD OF PRODUCTION OF NANO-PARTICLES OF SOLID DISPERSION AMORPHES BY CONTROLLED CO-PRECIPITATION USING MICROREACTORS / MICROFLUIDIZATION WITH THE INTUITE TO PROMOTE THE INTERACTION / MIXTURE AT THE MOLECULAR LEVEL OF THE CURRENTS INVOLVED IN THE PROCESS. THE PREPARATION METHOD CONSISTS OF TWO CURRENTS, A SOLVENT AND AN ANTI-SOLVENT, WHICH ARE ENGAGED BY A HIGH PRESSURE PUMP, TO CONTROLLED INDEPENDENTLY, AND FORCED TO INTERACT ON MICROCANAIS AND / OR MICROCACTORS. The invention also describes soluble scattering produced in accordance with the method of preparation of the invention and the use of solid amorphous dispersions in the formulation of a pharmaceutical form.