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METHOD FOR ASSESSING EFFECT OF HEPATOPROTECTIVE DRUGS ON CYTOLYSIS IN RAT BLOOD SERUM WITH TOXIC HEPATITIS

机译:评估肝毒性药物对毒性肝炎大鼠血清细胞溶解的影响的方法。

摘要

The method for assessing the effect of hepatoprotective drugs on the cytolysis in rat blood serum with toxic hepatitis includes blood tests. In the setting of the toxic hepatitis, the following substances are given to the rats once a day as a gavage: selenase at a dose of 50 µg/kg, ademethionine at a dose of 100 mg/kg, epadol at a dose of 100 mg/kg, livonorm at a dose of 100 mg/kg, detoxyl at a dose of 100 mg/kg. Thee cytolysis level and anticytolitic activity of the substances are assessed. The findings are compared with controls to ascertain the effects of the substances under study on the cytolysis in rat blood serum.
机译:评估肝保护药物对中毒性肝炎大鼠血清中细胞溶解的影响的方法包括血液测试。在发生中毒性肝炎的情况下,每天一次将下列物质作为管饲法给予大鼠:硒酸酶的剂量为50 µg / kg,乙二胺甲硫氨酸的剂量为100 mg / kg,依帕多尔的剂量为100 mg / kg,livonorm的剂量为100 mg / kg,去毒基的剂量为100 mg / kg。评估了这些物质的细胞溶解水平和抗细胞凋亡活性。将这些发现与对照进行比较,以确定所研究物质对大鼠血清中细胞溶解的影响。

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