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NATURALLY-DERIVED COMPOSITIONS FROM CALAMUS ORNATUS FOR ANTI-INFLAMMATORY APPLICATIONS
NATURALLY-DERIVED COMPOSITIONS FROM CALAMUS ORNATUS FOR ANTI-INFLAMMATORY APPLICATIONS
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机译:蒲的天然来源组合物,用于抗炎应用
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摘要
This invention pertains to derivatives of Calamus ornatus extracts and pure compound derivatives consistent with spirostanol saponins as selective inhibitors of cyclooxygenase 2 (COX-2). Activation of COX-2 is implicted with intense inflammation and pain, as well as other biological processes such as oncogenesis, angiogenesis and even for bowel movement. Hence, such activity of the compositions against COX-2 makes it a promising anti-inflammatory agent. With its different structure from the traditional COX-2 inhibitors, as well as the use of the source plant as a traditional food source, it is also likely that the invention might be safer to use, acutely or chronically. A combination with Garcinia binucao, which has its own anti-inflammatory properties, reduces the anit-motility effect of Calamus ornatus components while retaining its anti-inflammatory potency.
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