Na / K-ATPase ligands, ouabain antagonists, assays and use thereof

摘要

A Na / K-ATPase ligand, comprising at least one hydroxyl xanthone derivative having the structure: ** Formula ** wherein R1 = R2 = R6 = R7 = R8 = H, and R3 = R4 = R5 = OH, specifically 3,4,5-trihydroxyxanthone (MB5); or R1 = R2 = R7 = R8 = H, and R3 = R4 = R5 = R6 = OH, specifically 3,4,5,6-tetrahydroxixanthone (MB7), for use in treatment of cardiac hypertrophy, tissue fibrosis and / or congestive heart failure.