Modulation of growth hormone receptor expression and IGF-I

摘要

A modified oligonucleotide of from 12 to 30 nitrogenous bases long, where said oligonucleotide has a sequence of nitrogenous bases that have 100% complementarity with a growth hormone receptor RNA, where the internucleoside linkages of said oligonucleotide are modified, and wherein said oligonucleotide inhibits the expression of the growth hormone receptor and insulin-like growth factor-I, for use in the treatment or prophylaxis of a disease or condition associated with the expression of the growth hormone receptor and insulin-like growth factor-I, where the disease or condition is acromegaly, gigantism, age-related macular degeneration, diabetic retinopathy, diabetic nephropathy, diabetes, or growth hormone-dependent cancers or tumors Insulin-like growth I.