Abiraterone preparation process or abiraterone acetate

摘要

A process of preparing abiraterone or abiraterone acetate according to the scheme: ** ** Formula wherein X may be hydrogen or an acetyl radical CH3-C (O) -, said process comprising: - a first step It involves the reaction of dehydroepiandrosterone acetate or dehydroepiandrosterone (III) with a bis (trifluoromethanesulfonimide) aromatic of general formula Ar-N (Tf) 2, wherein Ar denotes an aromatic radical other than phenyl, and the group N (Tf) 2 is the radical: ** ** Formula in the presence of a base selected from alkali metal alcoholates; and - a second step of reacting the resulting mixture of said first step with dietilpiridilborano in the presence of a palladium (II).