Methods to determine the risk of chromosomal abnormalities in a fetus

摘要

A method for determining the risk of a chromosomal abnormality in a fetus, the method comprising: determining one or more ultrasound markers in the fetus; determine the amount of placental growth factor (PIGF), plasma protein associated with pregnancy A (PAPP-A) and free human chorionic gonadotropin (free beta hCG) in one or more blood samples taken from a pregnant woman; and determine the risk of the chromosomal abnormality in the fetus using the one or more ultrasound markers of the fetus and the measured amounts of PIGF, PAPP-A and free beta hCG.