USE OF LANTHANIDE-BASED NANOPARTICLES AS RADIOSENSITIZING AGENTS

摘要

The invention relates to the use of nanoparticles with dimensions of between 1 and 50 nm, at least part of which consists of at least one oxide and / or one oxohydroxide of at least one lanthanide, said nanoparticles being: at least one oxide and / or an oxohydroxide of at least one lanthanide, or in the form of nanoparticles comprising an oxohydroxide core of at least one lanthanide, and a coating consisting of a polysiloxane, optionally with organic molecules grafted on the surface; or included therein, as a radio-sensitizing agent in the manufacture of an injectable composition for improving the efficacy of tumor treatment by X or gamma irradiation. It also relates to nanoparticles which are particularly suitable for the above use, consisting of a core consisting of at least one oxide and / or an oxohydroxide of at least one lanthanide and a polysiloxane coating comprising 1 to 5 silicon. by lanthanide and of which at least 10% of the silicon atoms are bound to hydrophilic organic molecules with molar masses of less than 450 g / mol.