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SELF-DRYING DOSAGE FORM WITH CONTROLLABLE DRYING TIME AND DRYING RATE
SELF-DRYING DOSAGE FORM WITH CONTROLLABLE DRYING TIME AND DRYING RATE
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机译:具有可控制的干燥时间和干燥速率的自干燥剂型
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摘要
A self-drying pharmaceutical dosage form and a process for its manufacture are provided. The process involves the binding of water provided by a syrup of one or more pharmaceutically acceptable sugar(s), sugar alcohol(s) or salt(s), or mixtures thereof used for formulation by a suitable water-acceptor, selected from CaO and/or MgO that form a stable hydrate at room temperature. The inventive process allows to directly form ready-to-use castings without involving any physical drying, tableting or extrusion steps. The process further allows for industrial scale application, since the drying time and drying rate can be controlled and fine tuned by varying choice or ratio of the water-acceptor and by optionally further adding a pharmaceutically acceptable acid.
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