LONG-ACTING ENTEROCRININ POLYPEPTIDE ANALOGUE FOR TREATING TYPE 2 DIABETES AND USES THEREOF

摘要

Provided are a GLP-1 analogue and uses thereof. The GLP-1 analogue has the following general formula: HAEGTFTSDVSSYLEGQAAKEFIAWLX₂₇KX₂₉RX₃₁n₁YCZ, wherein X₂₇ is valine or cysteine, X₂₉ is glycine or cysteine, X₃₁ is glycine or cysteine, and at least one of X₂₇, X₂₉ and X₃₁ is cysteine; n₁Y represents n₁ Ys, n₁=1-10, and Y is glycine, alanine or valine; Z represents amino saturated fatty acid; and two cysteines contained in the general formula both form disulfide bonds. The GLP-1 analogue of the present invention can effectively increase the blood half-life period of GLP-1 and can be used for treating diabetes and adiposis.