METHOD FOR PREPARING ANTI-ANGIOGENIC COMPOUND AND INTERMEDIATE THEREOF

摘要

Disclosed is a method for preparing an anti-angiogenic compound represented by formula (I). The method comprises the step of reacting a compound of formula (II) with a compound of formula (III) in the presence of Cs2CO3 in a polar organic solvent to produce the compound of formula (I). According to the method of the present invention, by reacting the compound of formula (III) with the compound of formula (II) directly without protecting amino group in the compound of formula (III) under a certain condition, the yield is greatly improved, the synthetic method becomes simpler, the cost is also greatly reduced, and the commercial synthesis of the compound of formula (I) becomes possible. The preparation method for intermediate thereof is also disclosed.