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Use of SHROOM3 in chronic kidney disease and Chronic Allograft Nephropathy

机译:SHROOM3在慢性肾脏疾病和慢性同种异体肾病中的用途

摘要

A method for identifying the risk of developing Chronic Allograft Nephropathy (CAN) in a patient that received a kidney transplant from a donor which comprises identifying the race of the donor; determining the levels of SHROOM 3 expression in a kidney biopsy specimen obtained from the patient at a predetermined time after transplant; comparing the level of SHROOM 3 expression in the biopsy specimen with the levels of SHROOM 3 expression in a control; determining if the level of SHROOM 3 expression in the allograft is significantly higher than in the control, and diagnosing the patient as being at risk for CAN if the level of SHROOM 3 expression in the specimen is significantly higher than in the control.
机译:一种在接受来自供体的肾脏移植的患者中发展为慢性同种异体移植肾病(CAN)的风险的方法,该方法包括鉴定供体的种族。确定在移植后预定时间从患者获得的肾脏活检样本中SHROOM 3表达的水平;比较活检样本中SHROOM 3的表达水平与对照中SHROOM 3的表达水平;确定同种异体移植物中SHROOM 3表达水平是否显着高于对照,如果样本中SHROOM 3表达水平显着高于对照,则诊断患者存在CAN风险。

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