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Therapeutic agent comprising humanized anti-Epiregulin antibody as active ingredient for non-small-cell lung carcinoma excluding adenocarcinoma
Therapeutic agent comprising humanized anti-Epiregulin antibody as active ingredient for non-small-cell lung carcinoma excluding adenocarcinoma
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机译:包含人源化抗上皮调节蛋白抗体作为活性成分的治疗剂,用于治疗腺癌以外的非小细胞肺癌
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摘要
The present inventors succeeded in producing: an anti-Epiregulin antibody exhibiting a cross-species reactivity between a non-human animal crab-eating monkey and a human animal; an anti-Epiregulin antibody with suppressed chemical decomposition; an anti-Epiregulin antibody having a lowered isoelectric point; an anti-Epiregulin antibody having an elevated thermal denaturation midpoint temperature; and an anti-Epiregulin antibody having a reduced amount of aggregates, by appropriately substituting an amino acid residue in the variable region sequence of a humanized EP27 antibody that is capable of exhibiting a cytotoxic activity and neutralization activity on a cancer cell, said cancer cell expressing human Epiregulin, to thereby inhibit the proliferation of the cancer cell. Also, the present inventors succeeded in creating a therapeutic agent for non-small-cell lung carcinoma excluding adenocarcinoma, said therapeutic agent comprising one of the aforesaid antibodies as an active ingredient.
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