DYRK1AA GENE-DELETED ZEBRAFISH MODEL, AND METHOD FOR PREVENTING ANGIOGENESIS DEFECTS AND SCREENING FOR THERAPEUTIC AGENT BY USING SAME

摘要

The present invention relates to a dyrk1aa gene-deleted zebrafish model and a method for preventing angiogenesis defects and screening for a therapeutic agent by using the same. It has been confirmed from the mutant zebrafish of the present invention that the dyrk1aa gene plays an essential role in angiogenesis and in blood vessel maintenance, and an analysis of the mutant zebrafish can be utilized in research on the mechanisms of angiogenesis and blood vessel maintenance by the dyrk1aa gene and in screening for a small molecule.