USE OF HUNTINGTIN-DERIVED PLASMIDS AND PEPTIDES FOR ACTIVE IMMUNIZATION AS A HUNTINGTON'S DISEASE (HD) THERAPEUTIC

摘要

The present invention relates to, inter alia, therapeutics and therapeutic methods for treating Huntington's disease (HD). In one aspect, the present invention relates to the use of Huntingtin-derived plasmids and peptides for active immunization as a Huntington's disease (HD) therapeutic. In one embodiment, the immunogen used as the therapeutic comprises a peptide of human HTT protein. In particular embodiments, the peptide of human HTT protein is selected from the group consisting of N17 (first 17 residues of exon1), PP (residues 49-60), and EM48 (residues 74-88). In other embodiments, the immunogen comprises a combination of peptides of human HTT protein, including, without limitation, where the combination of peptides of human HTT protein comprises at least one of the peptides selected from the group consisting of N17, PP, and EM48.