CRYSTALLINE ARB-NEPI COMPOUND AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF

摘要

Disclosed are a crystalline ARB-NEPi compound and a preparation method therefor and an application thereof. The ARB-NEPi compound refers to [3-((1S, 3R)-1-biphenyl-4-ylmethyl-3-ethyloxycarbonyl-1-butylcarbamoyl)propionic acid-(S)-3'-methyl-2'-(valeryl{2"-(tetrazol-5-yl)biphenyl-4'-ylmethyl}amino)butyric acid]Na₃·X H₂O. Also disclosed are a pharmaceutical composition containing an effective amount of crystalline [3-((1S, 3R)-1-biphenyl-4-ylmethyl-3-ethyloxycarbonyl-1-butylcarbamoyl)propionic acid-(S)-3'-methyl-2'-(valeryl{2"-(tetrazol-5-yl)biphenyl-4'-ylmethyl}amino)butyric acid]Na₃·X H₂O and an application thereof in the preparation of drugs for treating or preventing neutral endopeptidase-related diseases, cardiovascular diseases, hypertension, acute or chronic heart failures such as congestive heart failures, left ventricular dysfunction, hypertrophic cardiomyopathy, diabetic cardiomyopathy, supraventricular and ventricular arrhythmia, atrial fibrillation, atrial flutter, or harmful vascular remodeling.