INFLAMMATION TARGETED NEUTROPHIL GRANULOCYTE DRUG DELIVERY SYSTEM AND USE THEREOF

摘要

Disclosed is an inflammation targeted neutrophil granulocyte drug delivery system and use thereof, wherein the drug delivery system consists of neutrophil granulocytes and a therapeutic substance or a detectable substance loaded into the neutrophil granulocytes or to the surface of the neutrophil granulocytes in a direct or indirect way. Using neutrophil granulocytes as the carrier of the drug can actively target the drug to an inflammatory site, and increase the drug concentration at the inflammatory site. The neutrophil granulocytes arriving at the inflammatory site will be abnormally activated under the stimulation of cytokines, rapidly disintegrate and die in the way of "skynet". This helps to rapidly release the loaded drug to the targeted site, so as to improve the therapeutic effect and reduce the toxic and side-effects.