MEDICAMENT DESIGN POCKET OF ORNITHINE DECARBOXYLASE AND APPLICATION OF MEDICAMENT DESIGN POCKET

摘要

Disclosed is a medicament design pocket of ornithine decarboxylase. On the basis of a crystal structure of human ornithine decarboxylase (ODC), the area of a binding site of putrescine and pyridoxal phosphate (PLP) ligands on a homodimer interface of the ornithine decarboxylase (ODC) is a medicament pocket. The medicament pocket can be used for screening, designing or transforming an inhibitor of human ornithine decarboxylase or non-human ornithine decarboxylase, or screening, designing or transforming an inhibitor of a protein highly homogenous with the binding site of putrescine and pyridoxal phosphate on the homodimer interface of the ornithine decarboxylase.