GENERAL SECRETORY PATHWAY (GSP) MUTANT LISTERIA SPP., AND METHODS FOR MAKING AND USING THE SAME

摘要

General secretory pathway (GSP) mutant Listeria bacteria are provided. Aspects of the bacteria include the presence of a GSP mutation, e.g., a SecY and/or SecA mutation. Also provided are methods of making and using the Listeria bacteria comprising a GSP mutation as vectors and vaccines expressing a heterologous nucleic acid.