POLYPEPTIDE CAPABLE OF SPECIFICALLY BINDING WITH TRB3 PROTEIN, SCREENING METHOD THEREFOR, AND IDENTIFICATION AND USE THEREOF

摘要

Disclosed are three polypeptides capable of specifically binding with human pseudo kinase tribbles 3 (TRB3). The polypeptides have the following amino acid sequences: B1: Ser-Leu-Ser-Gln-Met-Leu-Ser-Met, A2: Gly-Gly-Trp-Leu-Thr-Arg-Leu-Leu-Gln-Thr-Lys, and B3: Ile-Gly-Ala-Ala-Leu-Asp-Thr-Ile. The polypeptides are capable of blocking the binding between the TRB3 and P62 protein and can be used for development of vaccines or drugs for inhibiting the growth and transfer of tumor cells.