CHIMERIC NUCLEASE FOR SPECIFICALLY RECOGNIZING AND REPAIRING Β THALASSEMIA BETA-GLOBIN GENE

摘要

Disclosed is chimeric nuclease TALE-ISceI, in which FokI in TALEN is replaced with fusion protein obtained by transformed I-SceI. The chimeric nuclease TALE-ISceI can specifically recognize and repair a β thalassemia β-globin gene and can be used for treating β-thalassemia.