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PHARMACEUTICAL COMPOSITIONS FOR INCREASING THE BIOAVAILABILITY OF POORLY SOLUBLE DRUGS

机译：药物组合物，用于提高难溶性药物的生物利用度

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摘要

Pharmaceutical compositions comprising poorly soluble compounds, such as BCS class II or class IV drugs (e.g. amuvatinib), are provided. The pharmaceutical compositions are effective for increasing the bioavailability of the compounds. Related kits and methods are also provided.

机译：提供了包含难溶性化合物的药物组合物，例如II类BCS或IV类BCS药物（例如I. amuvatinib）。药物组合物对于增加化合物的生物利用度是有效的。还提供了相关的试剂盒和方法。 展开▼

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公开/公告号WO2016090240A1

专利类型

公开/公告日2016-06-09

原文格式PDF

申请/专利权人 ASTEX PHARMACEUTICALS INC.;JOSHI-HANGAL RAJASHREE;REDKAR SANJEEV;TANG CHUNLIN;
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申请/专利号WO2015US63982

发明设计人 JOSHI-HANGAL RAJASHREE;REDKAR SANJEEV;TANG CHUNLIN;
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申请日2015-12-04

分类号A61K31/519;C07D491/048;

国家 WO

入库时间 2022-08-21 14:17:35

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1. 一种能提高难溶性药物溶解性和生物利用度的组合物 [P] . 中国专利： CN103285401A . 2013-09-11

2. 提高难溶性药物溶解性能以提高生物利用度的方法 [P] . 中国专利： CN102406939B . 2013.05.08

3. PHARMACEUTICAL COMPOSITIONS FOR INCREASING THE BIOAVAILABILITY OF POORLY SOLUBLE DRUGS [P] . 美国专利： US2017360791A1 . 2017-12-21

机译：药物组合物，用于提高难溶性药物的生物利用度

4. COMPOSITION OF EXCIPIENTS AND PHARMACEUTICAL FORMS WITH SUSTAINED RELEASE AND INCREASED BIOAVAILABILITY OF ANTIBACTERIAL DRUGS, ANTICOCCIDIAL DRUGS AND OTHER DRUGS FOR COMMERCIAL POULTRY AND PIGS. [P] . MX347401B . 2017-04-18

机译：抗菌药物，抗菌药物和其他用于家禽和猪的药物的持续释放和增加的生物利用度的赋形剂和药物形式的组成。

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机译：持续释放的抗菌药物，抗菌药物和其他用于家禽和猪用药物的赋形剂和药物形式的组成

1. Nanocrystals for enhancement of oral bioavailability of poorly water-soluble drugs [J] . Varaporn Buraphacheep Junyaprasert, Boontida Morakul 亚洲药物制剂科学(英文) . 2015,第001期

2. Prodrugs incorporated into nanotechnology-based drug delivery systems for possible improvement in bioavailability of ocular drugs delivery [J] . Tiantian Ye, Kun Yuan, Wenji Zhang, 亚洲药物制剂科学(英文) . 2013,第004期

3. Multicomponent cyclodextrin system for improvement of solubility and dissolution rate of poorly water soluble drug [J] . Mayank Patel, Rajashree Hirlekar 亚洲药物制剂科学(英文) . 2019,第001期

4. Development,characterization and solubility enhancement of comparative dissolution study of second generation of solid dispersions and microspheres for poorly water soluble drug [J] . Poovi Ganesan, Rajpriyadarsini Soundararajan, Uma Shanmugam, 亚洲药物制剂科学(英文) . 2015,第005期

5. Pharmaceutical particle technologies: An approach to improve drug solubility, dissolution and bioavailability [J] . Prakash Khadka, Jieun Ro, Hyeongmin Kim, 亚洲药物制剂科学(英文) . 2014,第006期

6. Pharmaceutical particle technologies: An approach to improve drug solubility, dissolution and bioavailability [J] . Prakash Khadka, Jieun Ro, Hyeongmin Kim, Asian Journal of Pharmaceutical Sciences . 2014,第6期

7. Increasing Bioavailability of Poorly Water-Soluble Drugs by Technological Methods Facilitating Drug Dissolution [J] . L. Oká?ová, D. Vetchy, A. Franc, Chemicke Listy . 2011,第1期

8. Novel nanostructured drug delivery technology to enhance bioavailability, increase solubility and drug loading [C] . G. Heltovics, Zs. Otvos, G. Filipcsei, NSTI-Nanotech 2010;NSTI nanotechnology conference and expo;Bio Nanotech 2010;NSTI bio nano conference and expo;Microtech 2010;Microtechnology conference and expo;WCM 2010;Workshop on compact modeling;NSTI nanotech ventures;TechConnect summit;Clean technology . 2010

9. Improved Bioavailability and Site Specific Delivery of Poorly Water Soluble Drugs through the Production of Stabilized Drug Nanoparticles. [D] . Vaughn, Jason Michael. 2010

10. Pharmaceutical Dispersion Techniques for Dissolution and Bioavailability Enhancement of Poorly Water-Soluble Drugs [O] . Xingwang Zhang, Huijie Xing, Yue Zhao, 2018

11. Pharmaceutical particle technologies: An approach to improve drug solubility, dissolution and bioavailability [O] . Prakash Khadka, Jieun Ro, Hyeongmin Kim, 2014

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