Novel nanostructured drug delivery technology to enhance bioavailability, increase solubility and drug loading

摘要

Nanotechnology provides new innovative solutions for original as well as generic applications in a wide variety of industries including Pharmaceuticals, cosmetics, foods, nutraceuticals and home care. Nanoformulation is the reduction of particles size down to below 200 nm. This size reduction below 200 nm by using continuous flow nano precipitation technology led to 100s fold higher solubility and 10~(3-4) fold increased drug concentration in a stable colloid solution. In the paper we will discuss the perspectives and pharmacokinetic benefits of the nanostructured active molecules over the parent active molecules. The bioavailability of reference and nanostructured drug was determined after oral administration (30 mg/kg) in fasted state at Sprague-Dawley rats. Nanosized drug had an AUC_(15-360) min value of 6412 μmin/ml while this value after reference treatment was 940.1 μg-min/ml. The ratio of the two AUC values(AUC_(15-360 min (nanosized)) / AUC_(15-360 min (reference)) was 6.82.